Ttk cancer
WebTTK has emerged as a promising therapeutic target in human cancers, including triple-negative breast cancer (TNBC). Several TTK inhibitors (TTKis) are being evaluated in clinical trials, and an understanding of the mechanisms mediating TTKi sensitivity and resistance could inform the successful development of this class of agents. WebDec 7, 2024 · In addition, TTK has been discovered to function as an oncogene in various cancers [12,13,14, 18,19,20,21], and TTK inhibition has already been studied as a targeted …
Ttk cancer
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WebJul 1, 2024 · The expression of TTK kinase in gastric cancer is significantly higher than that of normal gastric immortalized cells, and its function is crucial for the proliferation and survival of gastric cancer cells. Knockdown of TTK results in decreased cell proliferation and increased rates of apoptosis and necrosis. WebApr 23, 2024 · TTK acted as an oncogene in liver cancer and indicator of poor survival prognosis. • TTK inhibitor increase radiosensitivity in liver cancer. • TTK inhibitor promote …
WebApr 23, 2024 · TTK acted as an oncogene in liver cancer and indicator of poor survival prognosis. • TTK inhibitor increase radiosensitivity in liver cancer. • TTK inhibitor promote liver cancer cells to accumulate in the G2/M phase. • TTK inhibitor enhances DNA damage with more γ-H2AX foci and more apoptosis and necrosis induced by radiation. • WebJan 1, 2024 · TTK is overexpressed in various cancers and has previously been studied as a target for the treatment of BC, glioblastoma, ovarian cancer, colon cancer, and others (18, 19, 32–35). TTK has been well characterized for its role in the spindle assembly checkpoint (SAC) complex, which prevents progression from metaphase to anaphase in mitosis when …
WebMay 20, 2013 · Triple-negative breast cancer (TNBC) represents a subgroup of breast cancers (BC) associated with the most aggressive clinical behavior. No targeted therapy is currently available for the treatment of patients with TNBC. In order to discover potential therapeutic targets, we searched for protein kinases that are overexpressed in human … WebAug 1, 2015 · TTK inhibitors are anticipated to be more active in SAC dependent tumors and data in the literature suggests that triple negative breast cancer is among the tumor types potentially highly dependent on TTK activity. Moreover, in accelerating mitosis, TTK inhibitors have a novel mode of action as compared to currently known mitotic inhibitors.
WebTTK is a prognostic biomarker for endometrial cancer[8]. Targeting TTK is a promising strategy for cancer treatment, and several TTK inhibitors are being tested in pre-clinical studies and clinical trials[9]. For example, TTK inhibitor AZ3146 induces cell cycle arrest of liver cancer cells, and
WebInhibition of TTK alters cell-cycle progression and exacerbates centrosome abnormalities, thus promoting the radiosensitivity of liver cancer cells in a p21-mediated manner [28]. ... incessantly ticking clock wowWebFeb 25, 2024 · Cancer-testis antigens (CTAs) are often expressed in tumor and testicular tissues but not in other normal tissues. To date, there has been no comprehensive study of the expression and clinical significance of CTA genes associated with endometrial cancer (EC) development. Additionally, the clinical relevance, biological role, and molecular … inactives week 8 nflincessantly ticking clock titanforgedWebSep 12, 2024 · Increase in TTK expression and its correlation with higher tumor grade, triple negative status, and worse overall survival in breast cancer.a–d Box plots of TTK gene … incessantly used in a sentenceWebApr 12, 2024 · Zhu, D. et al. Synthetic lethal strategy identifies a potent and selective TTK and CLK1/2 inhibitor for treatment of triple-negative breast cancer with a compromised G … incesu imam hatipWebAug 19, 2014 · TTK kinase is upregulated in pancreatic cancer. The mRNA levels of the TTK gene in primary pancreatic cancer and chronic pancreatitis tissues were determined using … inactives week 9 nflWebApr 5, 2016 · Mol Cancer Ther; 15(4); 583–92. ©2016 AACR. ... Monopolar spindle 1 (Mps1), also known as TTK, is a serine threonine kinase, which ensures proper biorientation of sister chromatids on the mitotic spindle by the activation of … incet m tab