The novel roles of circrnas in human cancer
Splet09. jan. 2024 · CircRNAs generally have low expression levels and relatively stable structures compared with messenger RNAs (mRNAs), most of which are located in the … SpletBiological Roles and Mechanisms of Circular RNA in Human Cancers Introduction. CircRNA has a covalent closed-loop structure and is highly stable and conservative special RNA, …
The novel roles of circrnas in human cancer
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Splet12. apr. 2024 · RNA interactions and their involvement in cancer. (a) Comparison of healthy (brown) and cancerous (red) cell interactomes in a hypothetical tumor. During … Splet02. sep. 2024 · An overview to the putative mechanisms, and functions of circRNAs in regulating OC pathogenesis in addition to their clinical potentials is given. Ovarian cancer …
Splet12. apr. 2024 · Herein, the potential function and molecular mechanism of circSmox in SCI pathological process was studied in vitro by treating differentiated PC12 cells, which are widely used as the model of neurons in vitro, 17 with the lipopolysaccharide (LPS), which may provide a novel insight into the pathogenesis of SCI. 2 MATERIALS AND METHODS Splet13. apr. 2024 · One of the key pathways for cellular growth is the phosphoinositide 3- kinase (PI3K)-mTOR (mechanistic/mammalian target of rapamycin) pathway. mTOR regulates the cellular response to nutrient availability. Dysregulation of the mTOR signaling pathway is intimately involved in many human diseases, especially the multitude of different human …
Splet11. maj 2024 · CircRNAs: role in human diseases and potential use as biomarkers Circular RNAs (circRNAs) are a class of endogenous RNAs characterized by a covalent loop … Splet21. mar. 2024 · Exosomal circular RNAs (circRNAs) played critical roles in tumor development and progression and might be novel biomarkers in the diagnosis and treatment of various cancers. However, the biological functions and clinical implications of exosomal circRNAs in breast cancer are unclear. Methods
Splet11. apr. 2024 · BackgroundGlioma is one of the deadliest malignant brain tumors in adults, which is highly invasive and has a poor prognosis, and long non-coding RNAs (lncRNAs) …
SpletPrevious studies have shown that circRNA circFAT1 plays opposite roles in gastric cancer and osteosarcoma. 14, 15 This study aimed to explore the role of circFAT1 in CRC. Patients and Methods Tissue Acquisition from CRC Patients hasta y asta son sinonimosSpletTo date, several translated circRNAs have been uncovered to play pivotal roles in human cancers. In this review, we introduced the properties and functions of circRNAs, and … p value t value and z valueSplet22. jan. 2024 · The regulatory roles of circular RNAs (circRNAs) in tumorigenesis have attracted increasing attention. However, novel circRNAs with the potential to be used as … hasta uttanasana stepsSpletGenerally, circRNAs function in cis is to enhance the expression of their parental genes. Similarly, some circRNAs also remain in the nucleus and are localized near the beginning of the transcription of their parental genes, possibly acting as positive regulators of Pol II and promoting the transcription of their parental genes ( Figure 1 B). hasta tu última muerteSpletMedulloblastoma (MB) develops through various genetic, epigenetic, and non-coding (nc) RNA-related mechanisms, but the roles played by ncRNAs, particularly circular RNAs … p value vs q valueSplet21. dec. 2024 · CircRNAs can remain stable in bodily fluids, such as in saliva, blood, urine, and especially plasma. The difference in the expression of plasma circRNAs between cancer patients and normal people may suggest that plasma circRNAs may play an important role in the occurrence and development of cancer. p value vs p valueSplet17. okt. 2024 · CircRNAs act as tumor suppressors or oncogenes to participate in the development of a variety of tumors and are becoming novel diagnostic and prognostic … p value vs null hypothesis