WebJ. had a myocardial infarction (MI) 3 years ago. He was prescribed gemfibrozil (Lopid) 600 mg, twice daily, before meals. His cholesterol remained between 220 and 240 mg/dL, and his LDL was 140 mg/dL. His anticholesterol drug was changed to simvastatin (Zocor) 20 mg/day in the evening. How does simvastatin differ from gemfibrozil? WebGemfibrozil is a lipid lowering agent used for the treatment of hypertriglyceridemia Mahley and Bersot (2001). It decreases serum triglycerides and very low density lipoprotein (VLDL) cholesterol and is of benefit in increasing high density lipoprotein (HDL) cholesterol. Gemfibrozil is a fibric acid derivative that is structurally similar to ...
Antihyperlipidemics Flashcards Quizlet
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High cholesterol - Diagnosis and treatment - Mayo Clinic
WebLopid (gemfibrozil) and Zocor (simvastatin) are used to treat high cholesterol and triglyceride levels. Zocor is also used to treat heterozygous familial hypercholesterolemia … WebFeb 13, 2024 · Gemfibrozil is mostly protein-bound (99%). It is metabolized hepatically into inactive metabolites, and it is excreted in the urine (70%) and feces (6%). The drug's half-life is approximately 1.5 hours, with a peak serum time of roughly 1 to 2 hours. Go to: Administration Dosage Gemfibrozil is available in 600 mg oral tablets. Web• Simvastatin is contraindicated for use concomitantly with azole antifungals, erythromycin antibacterials, HIV protease inhibitors, nefazodone, gemfibrozil, cyclosporine, and danazol. Patients who require a medication that interacts with simvastatin should be switched to an alternate statin that has less potential for the drug interaction. slow internet access speed