Higher stemness
Web17 de abr. de 2024 · High-stemness cancers might also be rendered more sensitive to immune control by administering drugs that induce cell differentiation to irreversibly disrupt the stemness phenotype . This might bring the additional benefit of constraining further tumor evolution, creating the conditions for durable clinical responses. Web19 de mai. de 2024 · We also observed a high degree of intertumoral heterogeneity in the expression of stemness- and proliferation-related genes, which was associated with increased hazard ratios in a fraction of tumors and mirrored by high intratumoral heterogeneity and a remarkable stemness capacity in metastatic lesions across cancer …
Higher stemness
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Web1 de dez. de 2009 · The newcomer state theory holds that stemness is a state of a cell characterized by a high degree of plasticity, where plasticity is the property of being transmutable into either a less committed or a more committed state. We argue that neither theory, as currently articulated, is satisfactory. Web23 de nov. de 2024 · Results: Stemness was significantly associated with overall survival (OS) and progress free survival (PFS) of DLBCL patients. Notably, prolonged OS and PFS was observed in low stemness groups compared to high group, and the international prognostic index (IPI) with a high risk had higher stemness.
Web13 de abr. de 2024 · Head and neck squamous cell carcinoma (HNSCC) is among the most severe and complex malignant diseases with a high level of heterogeneity and, as a result, a wide range of therapeutic responses ... WebHighness definition, the quality or state of being high; loftiness. See more.
Web9 de jun. de 2024 · CRC patients with higher stemness scores exhibited worse prognosis, more immunosuppressive components in TME and lower immunotherapeutic responses. Additionally, the model’s immunotherapeutic prediction efficacy was further confirmed from two immunotherapy cohorts (anti-PD-L1 in IMvigor210 cohort and anti-PD-1 in … WebIn the transcriptomic data from cell lines, we found a high level of stemness in HPV-tumour cells, despite the lack of significance in the data due to the small sample size (Figure 2A). We therefore studied the level of stemness of tumour cells using scRNA data, in which we can identify genes that are in a transitional state between two different cell fates.
Web7 de nov. de 2024 · Furthermore, they applied the stemness index analyze the transcriptome of TCGA and obtained the mRNA expression-based stem index (mRNAsi) of different types of tumors including GC, with the value between -1 and 1, and the higher the value of mRNAsi, the stronger properties of cancer stem cells.
Web21 de mar. de 2024 · The ability of the StemSC to identify stemness-associated genes and construct cellular differentiation trajectories Given the high correlation between StemSC values and differentiation time, we next explored the ability of the StemSC to identify the stem makers or differentiation factors. philtron electronicsWebThe mesenchymal phenotype has higher stemness and invasive potential a Ungated flow cytometry distribution of SW620, A549, and MDA-MB-231 cells by the … tsh prostateWeb6 de abr. de 2024 · We observed that intratumor heterogeneity was significantly higher in high-stemness than in low-stemness bulk tumors, but significantly lower in high-stemness than in low-stemness single cancer cells. phil trom city of san diegoWeb22 de jun. de 2024 · Stemness encompasses the capability of a cell for self-renewal and differentiation. The stem cell maintains a balance between proliferation, quiesc... Cell … tshp threadsWeb5 de ago. de 2024 · Here, we employed a trained stemness index model based on an existent one-class logistic regression (OCLR) machine-learning method to score MB samples; we then obtained two stemness indices, a gene expression-based stemness index (mRNAsi) and a DNA methylation-based stemness index (mDNAsi), to perform an … tsh proverWeb2 de set. de 2024 · Glioblastoma (GBM) is the most malignant and lethal intracranial tumor, with extremely limited treatment options. Immunotherapy has been widely studied in GBM, but none can significantly prolong the overall survival (OS) of patients without selection. Considering that GBM cancer stem cells (CSCs) pl … tsh psaWeb4 de ago. de 2024 · Here, we calculated stemness score 32 (see Materials and methods section) for each single HSPC, and found that HSPCs with a high stemness score from … philtron electrical