WebBufalin is an inhibitor of steroid receptor coactivator 3 (SRC-3). It acts by inducing cell death through the ROS-mediated RIP1/RIP3/PARP-1 pathways. ... Solubility: Soluble in … WebJun 15, 2016 · It was demonstrated that the solubility of PEGS-BUF was ∼17.3 mg/mL and BUF content was calculated to be ∼0.69 mg/mL, which was approximately 21-fold higher …
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WebSep 1, 2024 · Bufalin inclusion complex with β-cyclodextrin was prepared by co-precipitation method [36], [37]. A certain amount of β-CD was completely dissolved in double distilled water to receive a saturated solution. ... The solubility and in vitro dissolution revealed better water-solubility and dissolution rate of inclusion complex than that of …
WebNov 15, 2024 · Bufalin (BU) is one of the most effective antitumor active constituents in Chansu. Our previous study found that BU can effectively reverse P-glycoprotein (P-gp)-mediated MDR in colon cancer. However, the clinical application of BU is limited due to its low solubility in water and high toxicity. WebBufalin is an anti-metastasis drug [ 4], which elicits anti-tumor functionality by favoring cell cycle arrest and apoptosis in various cancer types including hepatocellular, bladder and osteosarcoma. [ 2] It also promotes autophagic cell death and possesses anti …
WebBufalin (0, 1, 2, 4 μM for 48 hours) decreases cell viability in NCI-H460 cells. Bufalin (2 μM) increases caspae-3, Endo G and GADD153 mRNA expression, but decreases the GRP78 mRNA expression. MCE has not … WebNov 29, 2024 · Bufalin (BFL) has excellent physiological activities such as defending tumors, improving cardiac function, and so on. However, due to its poor water-solubility and bioavailability, the clinical application of BFL remains limited. In order to improve bioavailability of BFL, in our previous research, a novel peptide-dendrimer (PD) was …
WebApr 11, 2024 · Also, in a similar study, Li et al. examined in situ phase transition from a microemulsion to a LLC toward the aim of controlled release of bufalin-loaded carriers containing medium chain capric/caprylic triglycerides (MCT), macrogol (15)- hydroxystearate (solutol HS 15), SMO and water which released nearly 48.3- 67.9 % of the cargo after 96 ...
WebSep 16, 2024 · Furthermore, we tested the water solubility of these glycosides and found that the water solubilities of the two glycosides were 13.1 and 53.7 times of bufalin, respectively. In addition, the inhibitory activity of these glycosides against Na +, K +-ATPase were evaluated. The mono-glycosylated compound showed more potent activity than … checks share codeWebThe solubility of bufalin in Arg4 + and Arg8 + dendrimer solution was 62.5 and 79.3 μg mL −1, respectively. Interestingly the solubility of bufalin in Arg4 + lipidated dendrimer significantly increased to 142.9 μg mL −1. … flat roofing companies iowaWebJul 27, 2012 · Bufalin-loaded mPEG-PLGA-PLL-cRGD nanoparticles: preparation, cellular uptake, tissue distribution, and anticancer activity. Background: Recent studies have shown that bufalin has a good antitumor effect but has high toxicity, poor water solubility, a short half-life, a narrow therapeutic window, and a toxic dose that is close to … flat roofing companies in torquayWebMay 1, 2013 · Bufalin (Fig. 1) is one of major components of Chan’Su, and its content in the crude drug can be as high as 1–5% of the dry weight. It also is one of the most potent bufadienolides against cancer cells, ... substituents could be advantageously grafted on C3 of bufalin to increase activity while simultaneously increasing solubility. N ... check ssh centos 7WebSep 1, 2024 · Bufalin (BF), a traditional Chinese medicine, exhibited inhibitory activities against a broad spectrum of tumor cells. The present study elaborates that bufalin was successfully encapsulated into the cavity of β-cyclodextrin (β-CD), which was determined by Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance … check ssh ciphersWebMar 27, 2024 · As mentioned above, bufalin has a significant antitumor effect in a variety of tumors. However, due to high toxicity, poor water solubility, fast metabolism, short half-life, its application is seriously limited in cancer therapy. The formation of nano-carriers is an effective way to improve the therapeutic effect of bufalin. flat roofing companies kitchenerWebMay 25, 2024 · Introduction. Bufalin (BF) is one of the key active components of the traditional Chinese medicine ChanSu, which is derived from secretions from the skin and parotid venom glands of Bufo gargarizans Cantor or Bufo melanostictus Schneider. 1 As a typical representative of cardiac glycosides, BF recently has been found to have … check ssh ciphers nmap